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LAT Antibody : Biotin (ARP31777_P050-Biotin)

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100 ul
$125.00
In Stock

Conjugation Options

ARP31777_P050 Unconjugated

ARP31777_P050-FITC Conjugated

ARP31777_P050-HRP Conjugated

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Gene Symbol:
LAT
NCBI Gene Id:
27040
Official Gene Full Name:
linker for activation of T cells
Protein Name:
Linker for activation of T-cells family member 1
Swissprot Id:
O43561
Protein Accession #:
NP_055202
Nucleotide Accession #:
NM_001014987
Alias Symbols:
LAT1, pp36,
Description of Target:
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein Size (# AA):
262
Molecular Weight:
28 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express LAT.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express LAT.
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%
Complete computational species homology data:
Anti-LAT (ARP31777_P050)
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution and Storage:
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Concentration:
1 mg/ml
Protein Interactions:
UBC; TRAF6; SGTA; LCP2; ZAP70; PLCG1; ALB; ZHX2; SPRY1; SOS1; LCK; GRB2; FYN; CBL; CD247; CD3E; USP19; CD244; GAB2; GRAP2; GRAP; SH3BP2; MAP4K1; SLA; PTPRJ; SHB; PLCG2; SYK; ITK; CD4; CD8A; PTPN1; VAV1; FCGR2A; FCGR1A; CLYBL; PIK3R1;
Blocking Peptide:
Available upon request
Datasheets/Manuals:
Printable datasheet for anti-LAT (ARP31777_P050-Biotin) antibody
Conjugation:
Biotin

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