LAMP1 Antibody (OAEE00598)

Catalog No: OAEE00598

Size:100T

Surface staining of human peripheral blood cells with anti-CD107a (H4A3) PE.

Product Info

• Predicted Species Reactivity: Human|Mouse|Non-human Primate
• Product Format: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Clonality: Monoclonal
• Clone: H4A3
• Isotype: IgG1
• Host: Mouse
• Conjugation: APC
• Application: Flow cytometry
• Reconstitution and Storage: 2°C to 8°C
• Immunogen: Human PBMC
• Purification: Purified by size-exclusion chromatography
• Concentration: 10 ul / test
• Specificity: The mouse monoclonal antibody H4A3 recognizes CD107a, an approximately 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.
• Formulation: APC
• Storage Buffer: The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
• Reference: Mao H, Tu W, Liu Y, Qin G, Zheng J, Chan PL, Lam KT, Peiris JS, Lau YL: Inhibition of human natural killer cell activity by influenza virions and hemagglutinin. J Virol. 2010 May;84(9):4148-57.
  Yu CI, Gallegos M, Marches F, Zurawski G, Ramilo O, García-Sastre A, Banchereau J, Palucka AK: Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines. Blood. 2008 Nov 1;112(9):3671-8.
  Tomescu C, Chehimi J, Maino VC, Montaner LJ: NK cell lysis of HIV-1-infected autologous CD4 primary T cells: requirement forIFN-mediated NK activation by plasmacytoid dendritic cells. J Immunol. 2007 Aug 15;179(4):2097-104.
  Carlsten M, Björkström NK, Norell H, Bryceson Y, van Hall T, Baumann BC, Hanson M, Schedvins K, Kiessling R, Ljunggren HG, Malmberg KJ: DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res. 2007 Feb 1;67(3):1317-25.
  Marcenaro S, Gallo F, Martini S, Santoro A, Griffiths GM, Aricó M, Moretta L, Pende D: Analysis of natural killer-cell function in familial hemophagocyticlymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4defect and discriminates between genetic subtypes of the disease. Blood. 2006 Oct 1;108(7):2316-23., Furuta K, Ikeda M, Nakayama Y, Nakamura K, Tanaka M, Hamasaki N, Himeno M, Hamilton SR, August JT: Expression of lysosome-associated membrane proteins in human colorectal neoplasms and inflammatory diseases. Am J Pathol. 2001 Aug;159(2):449-55.
  And many other.
  Mane SM, Marzella L, Bainton DF, Holt VK, Cha Y, Hildreth JE, August JT: Purification and characterization of human lysosomal membrane glycoproteins. Arch Biochem Biophys. 1989 Jan;268(1):360-78.
  Deetz CO, Hebbeler AM, Propp NA, Cairo C, Tikhonov I, Pauza CD: Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonistPam3Cys. Infect Immun. 2006 Aug;74(8):4505-11.
  

Target Info

• Gene Symbol: LAMP1
• Gene Full Name: lysosomal associated membrane protein 1
• Alias Symbols: CD107 antigen-like family member A;CD107a;LAMP-1;LAMPA;LGP120;lysosome-associated membrane glycoprotein 1;lysosome-associated membrane protein 1.
• NCBI Gene Id: 3916
• Protein Name: Lysosome-associated membrane glycoprotein 1
• Description of Target: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
• Uniprot ID: P11279
• Protein Accession #: NP_005552.3
• Nucleotide Accession #: NM_005561.3