LAMP1 Antibody (OAEE00052)

Catalog No: OAEE00052

Size:100UG

Surface staining of human peripheral blood cells with anti-CD107a (H4A3) PE.

Product Info

• Predicted Species Reactivity: Human, non-human primates, mouse
• Product Format: Liquid PBS (pH 7.4)
• Clonality: Monoclonal
• Clone: H4A3
• Isotype: IgG1 kappa
• Host: Mouse
• Application: FC, IF, IHC
• Reconstitution and Storage: Store at 2-8°C. Do not freeze.
• Immunogen: Human PBMC
• Purification: Purified by protein A affinity chromatography.
• Concentration: 1 mg/ml
• Specificity: The mouse monoclonal antibody H4A3 recognizes CD107a, an approximately 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.
• Application Info: WB: 1 ug/mL
  IHC: 2-8 ug/mL
  FC: Intracellular and extracellular staining. 1-12 ug/mL

Target Info

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  Carlsten M, Bjorkstrom NK, Norell H, Bryceson Y, van Hall T, Baumann BC, Hanson M, Schedvins K, Kiessling R, Ljunggren HG, Malmberg KJ: DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res. 2007 Feb 1;67(3):1317-25.
  Marcenaro S, Gallo F, Martini S, Santoro A, Griffiths GM, Arico M, Moretta L, Pende D: Analysis of natural killer-cell function in familial hemophagocyticlymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4defect and discriminates between genetic subtypes of the disease. Blood. 2006 Oct 1;108(7):2316-23.,
  Furuta K, Ikeda M, Nakayama Y, Nakamura K, Tanaka M, Hamasaki N, Himeno M, Hamilton SR, August JT: Expression of lysosome-associated membrane proteins in human colorectal neoplasms and inflammatory diseases. Am J Pathol. 2001 Aug;159(2):449-55.
  Mane SM, Marzella L, Bainton DF, Holt VK, Cha Y, Hildreth JE, August JT: Purification and characterization of human lysosomal membrane glycoproteins. Arch Biochem Biophys. 1989 Jan;268(1):360-78.
  Deetz CO, Hebbeler AM, Propp NA, Cairo C, Tikhonov I, Pauza CD: Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonistPam3Cys. Infect Immun. 2006 Aug;74(8):4505-11.
  
• Gene Symbol: LAMP1
• Gene Full Name: lysosomal associated membrane protein 1
• Alias Symbols: CD107 antigen-like family member A;CD107a;LAMP-1;LAMPA;LGP120;lysosome-associated membrane glycoprotein 1;lysosome-associated membrane protein 1.
• NCBI Gene Id: 3916
• Protein Name: Lysosome-associated membrane glycoprotein 1
• Description of Target: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
• Uniprot ID: P11279
• Protein Accession #: NP_005552.3
• Nucleotide Accession #: NM_005561.3