KRT17 Antibody (OAAF01844)

Catalog No: OAAF01844 (Formerly GWB-ASD115)

Size:100 ug

Western blot analysis of extracts from HuvEc cells, using Keratin 17 Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Keratin 17 Antibody. The picture on the right is treated with the synthesized peptide.

Immunofluorescence analysis of HepG2 cells, using Keratin 17 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human Keratin 17.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: Keratin 17 antibody detects endogenous levels of total keratin 17 protein.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB 1:500~1000
  IHC 1:50~100
  IF 1:100~500
  ELISA 1:20000
  
• Reference: M Rosenberg, Mol. Cell. Biol., Feb 1988; 8: 722 - 736.
  SM Troyanovsky, J. Cell Sci., Jul 1989; 93: 419.
  Kevin M. McGowan, Genes & Dev., Jun 2002; 16: 1412.
  Nicholas Bianchi, Mol. Cell. Biol., Aug 2005; 25: 7249 - 7259.

Target Info

• Gene Symbol: KRT17
• Gene Full Name: keratin 17
• Alias Symbols: 39.1;CK-17;cytokeratin-17;K17;keratin 17, type I;keratin, type I cytoskeletal 17;Keratin-17;PC;PC2;PCHC1.
• NCBI Gene Id: 3872
• Protein Name: Keratin, type I cytoskeletal 17
• Description of Target: Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
• Uniprot ID: Q04695
• Protein Accession #: NP_000413.1
• Molecular Weight: 48 kDa