Search Antibody, Protein, and ELISA Kit Solutions

KRAS Antibody - C - terminal region (OAAB11771)

200ul
$390.00
In Stock
Request Bulk Order Quote

Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. PBS with 0.09% (W/V) sodium azide.
Clonality:
Polyclonal
Isotype:
Ig
Host:
Rabbit
Application:
WB, IF, FC
Additional Information:
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner
Cellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
KRAS
NCBI Gene Id:
3845
Protein Name:
GTPase KRas
Swissprot Id:
P01116
Protein Accession #:
NP_004976.2
Alias Symbols:
GTPase KRas, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, GTPase KRas, N-terminally processed, KRAS, KRAS2, RASK2
Replacement Item:
This antibody may replace item sc-30 from Santa Cruz Biotechnology.
Description of Target:
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
Molecular Weight:
22 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express KRAS.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express KRAS.
Immunogen:
This KRAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-174 amino acids from the C-terminal region of human KRAS.
Predicted Homology Based on Immunogen Sequence:
Rat
Concentration:
0.5 mg/ml
Datasheets/Manuals:
Printable datasheet for OAAB11771
Intended Use:
For research use only and not for use in diagnostic or therapeutic procedures.
Application Info:
WB: 1:2000
WB: 1:500
IF: 1:10~50
FC: 1:10~50

Product Reviews

Tell us what you think about this item!

Write A Review
    Please, wait...