Catalog No: OPCD00716
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Datasheets/ManualsPrintable datasheet for KLRK1 Recombinant Protein (OPCD00716)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
ApplicationCtrl (+), SDS-PAGE, WB
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Phe90-Val232
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 90%
TagN-terminal His Tag
Gene SymbolKlrk1
Gene Full Namekiller cell lectin-like receptor subfamily K, member 1
Alias SymbolsD6H12S2489;D6H12S2489E;Killer cell lectin-like receptor subfamily K member 1;natural killer cell group 2D;NK cell receptor D;Nkg2;NKG2-;Nkg2d;NKG2-D;NKG2-D type II integral membrane protein;NKG2-D-activating NK receptor.
NCBI Gene Id27007
Protein NameNKG2-D type II integral membrane protein
Description of TargetFunction as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1.
Uniprot IDO54709
Protein Accession #NP_001076791.1
Nucleotide Accession #NM_001083322.2
Protein Size (# AA)Phe90~Val232
Molecular Weight20kDa
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