Catalog No: OAEE00203
Size:100UG
Price: $199.00
SKU
OAEE00203
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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KLRK1 Antibody (OAEE00203)

Datasheets/ManualsPrintable datasheet for KLRK1 Antibody (OAEE00203) (OAEE00203)
Product Info
Predicted Species ReactivityHuman
Product FormatPhosphate buffered saline (PBS), pH 7.4
ClonalityMonoclonal
Clone1D11
IsotypeIgG1
HostMouse
ApplicationFC
Reconstitution and Storage2°C to 8°C
ImmunogenNKL cell line
PurificationPurified
Concentration1 mg/ml
SpecificityThe mouse monoclonal antibody 1D11 recognizes CD314 / NKG2D, a 42 kDa C-type lectin-like activating receptor expressed by NK cells, gamma/delta T cells, and CD8+ T cells.
FormulationAzide free
Purity> 95% (by SDS-PAGE)
Storage BufferAzide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized.
ReferenceValencia J, Hernández-López C, Martínez VG, Hidalgo L, Zapata AG, Vicente A, Varas A, Sacedón R: Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors. J Leukoc Biol. 2010 Mar;87(3):405-14.
Ebert LM, Meuter S, Moser B: Homing and function of human skin gammadelta T cells and NK cells: relevance for tumor surveillance. J Immunol. 2006 Apr 1;176(7):4331-6.
Hasenkamp J, Borgerding A, Uhrberg M, Falk C, Chapuy B, Wulf G, Jung W, Trümper L, Glass B: Self-tolerance of human natural killer cells lacking self-HLA-specific inhibitoryreceptors. Scand J Immunol. 2008 Mar;67(3):218-29.
Sangiolo D, Martinuzzi E, Todorovic M, Vitaggio K, Vallario A, Jordaney N, Carnevale-Schianca F, Capaldi A, Geuna M, Casorzo L, Nash RA, Aglietta M, Cignetti A: Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers. Int Immunol. 2008 Jul;20(7):841-8.
Wu J, Groh V, Spies T: T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells. J Immunol. 2002 Aug 1;169(3):1236-40.
Wu J, Cherwinski H, Spies T, Phillips JH, Lanier LL: DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. J Exp Med. 2000 Oct 2;192(7):1059-68.
Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 1999 Jul 30;285(5428):727-9.
Gene SymbolKLRC4-KLRK1|KLRK1
Gene Full Namekiller cell lectin like receptor K1|KLRC4-KLRK1 readthrough
Alias SymbolsCD314;D12S2489E;killer cell lectin-like receptor subfamily K member 1;killer cell lectin-like receptor subfamily K, member 1;KLR;NK cell receptor D;NKG2D;NKG2-D;NKG2-D type II integral membrane protein;NKG2-D-activating NK receptor.
NCBI Gene Id100528032|22914
Protein NameNKG2-D type II integral membrane protein
Description of TargetFunction as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Uniprot IDP26718
Protein Accession #NP_001186734.1; NP_031386.2
Nucleotide Accession #NM_001199805.1; NM_007360.3
  1. What is the species homology for "KLRK1 Antibody (OAEE00203)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "KLRK1 Antibody (OAEE00203)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "KLRK1 Antibody (OAEE00203)" provided in?

    This item is provided in "Phosphate buffered saline (PBS), pH 7.4".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "KLRK1 Antibody (OAEE00203)"?

    This target may also be called "CD314;D12S2489E;killer cell lectin-like receptor subfamily K member 1;killer cell lectin-like receptor subfamily K, member 1;KLR;NK cell receptor D;NKG2D;NKG2-D;NKG2-D type II integral membrane protein;NKG2-D-activating NK receptor." in publications.

  5. What is the shipping cost for "KLRK1 Antibody (OAEE00203)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "KLRK1 Antibody (OAEE00203)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "KLRK1 Antibody (OAEE00203)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "KLRK1 Antibody (OAEE00203)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "KLRC4-KLRK1|KLRK1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "KLRC4-KLRK1|KLRK1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "KLRC4-KLRK1|KLRK1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "KLRC4-KLRK1|KLRK1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "KLRC4-KLRK1|KLRK1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "KLRC4-KLRK1|KLRK1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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