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Catalog No: OATA00568
Size:100 ug
Price: $79.00
SKU
OATA00568
Availability: Discontinued
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KLRG1 Antibody (OATA00568)

The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells.
The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations.
Datasheets/ManualsPrintable datasheet for OATA00568
Product Info
Tested Species ReactivityMouse
Product FormatLiquid 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, pH 7.2
ClonalityMonoclonal
Clone2F1
IsotypeGolden Syrian Hamster IgG
HostHamster
ConjugationUnconjugated
ApplicationFC, IP
Reconstitution and StorageStore at 2-8°C. Do not freeze.
PurificationPurified from tissue culture supernatant via affinity chromatography.
Concentration0.5 mg/ml
SpecificityKLRG1
Purity> 90%
Reference

Thaventhiran JED, Hoffmann A, Magiera L, de la Roche M, Lingel H, Brunner-Weinzierl M, and Fearon DT. 2012. Proc. Natl. Acad. Sci. 10.1073. (Flow cytometry).

Tessmer MS, Fugere C, Stevenaert F, Naidenko OV, Chong HJ, Leclercq G, and Brossay L. 2007. Int. Immunol. 19:391-400. (Immunoprecipitation, in vitro blocking, Flow cytometry)

Robbins SH, Nguyen KB, Takahashi N, Mikayama T, Biron CA, and Brossay L. 2002. J. Immunol. 168: 2585-2589. (in vitro blocking)

Hanke T, Corral L, Vance RE, and Raulet DH. 1998. Eur. J. Immunol. 28(12): 4409-4417. (Origination of 2F1 clone)

Gene SymbolKLRG1
Gene Full Namekiller cell lectin-like receptor subfamily G, member 1
Alias SymbolsMAFA, 2F1-A, 2F1-Ag, MAFA-L
NCBI Gene Id50928
Protein Namekiller cell lectin-like receptor subfamily G member 1
Uniprot IDO88713
Protein Accession #NP_058666.1
Nucleotide Accession #NM_016970.1
Molecular Weight30-38 kDa
  1. What is the species homology for "KLRG1 Antibody (OATA00568)"?

    The tested species reactivity for this item is "Mouse". This antibody is predicted to have homology to "".

  2. How long will it take to receive "KLRG1 Antibody (OATA00568)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "KLRG1 Antibody (OATA00568)" provided in?

    This item is provided in "Liquid 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, pH 7.2".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "KLRG1 Antibody (OATA00568)"?

    This target may also be called "MAFA, 2F1-A, 2F1-Ag, MAFA-L" in publications.

  5. What is the shipping cost for "KLRG1 Antibody (OATA00568)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "KLRG1 Antibody (OATA00568)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "KLRG1 Antibody (OATA00568)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "30-38 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "KLRG1 Antibody (OATA00568)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "KLRG1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "KLRG1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "KLRG1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "KLRG1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "KLRG1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "KLRG1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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