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KLRC1 Antibody (OAGA00688)

100 ul
$409.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
ICC, IF, IHC-FFPE, WB
Additional Information:
Background: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq]
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Positive Controls: A431, HepG2
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Cellular Localization: Membrane; Single-pass type II membrane protein
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Gene Symbol:
KLRC1
Official Gene Full Name:
NKG2-A/NKG2-B type II integral membrane protein
NCBI Gene Id:
3821
Protein Name:
NKG2-A/NKG2-B type II integral membrane protein
Swissprot Id:
P26715
Protein Accession #:
NP_002250.1
Alias Symbols:
CD159A antibody, MGC13374 antibody, MGC59791 antibody, NKG2 antibody, NKG2A antibody, KLRC1 antibody, NKG2-A/B-activating NK receptor antibody, NKG2-A/B type II integral membrane protein antibody, C-lectin type II protein antibody, CD159 antigen-like fami
Replacement Item:
This antibody may replace item sc-42946 from Santa Cruz Biotechnology.
Molecular Weight:
26 kDa
Purification:
Purified by antigen-affinity chromatography.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express KLRC1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express KLRC1.
Immunogen:
Synthetic peptide corresponding to a region within amino acids 1 and 45 of KLRC1 (Uniprot ID#P26715)
Concentration:
0.54 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-KLRC1 antibody - OAGA00688
Application Info:
Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-P: 1:100-1:1000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Storage Buffer:
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

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