KLK3 Antibody - middle region (ARP41879_P050)

Size:100 ul

Human THP-1 Whole Cell

Basic Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Dog, Human, Mouse, Rat
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Replacement Item: This antibody may replace item sc-116410 from Santa Cruz Biotechnology.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 77%; Human: 100%; Mouse: 86%; Rat: 86%
• Complete computational species homology data: Anti-KLK3 (ARP41879_P050)
• Peptide Sequence: Synthetic peptide located within the following region: LRPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSI
• Concentration: Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
• Blocking Peptide: For anti-KLK3 (ARP41879_P050) antibody is Catalog # AAP41879
• Datasheets/Manuals: Printable datasheet for anti-KLK3 (ARP41879_P050) antibody
• Publications:

  Alzghoul, S; Hailat, M; Zivanovic, S; Que, L; Shah, GV; Measurement of serum prostate cancer markers using a nanopore thin film based optofluidic chip. 77, 491-8 (2016). WB, Dog, Human, Mouse, Rat 26457734

Target Info

• Gene Symbol: KLK3
• Official Gene Full Name: Kallikrein-related peptidase 3
• Alias Symbols: APS, KLK2A1, PSA, hK3
• NCBI Gene Id: 354
• Protein Name: Prostate-specific antigen
• Description of Target: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
• Swissprot Id: P07288
• Protein Accession #: NP_001639
• Nucleotide Accession #: NM_001648
• Protein Size (# AA): 261
• Molecular Weight: 26kDa
• Tissue Tool: Find tissues and cell lines supported by DNA array analysis to express KLK3.
• RNA Seq: Find tissues and cell lines supported by RNA-seq analysis to express KLK3.
• Protein Interactions: ALB; PZP; SERPINA5; SERPINA1; SEMG2; SEMG1; PLG; PTHLH; IGFBP3; FN1; EPOR; SLPI; SERPINA3; A2M; POLR2A; AR; KAT5; RUVBL1; CTNNB1;