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Catalog No: OPCD04677
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OPCD04677
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Datasheets/ManualsPrintable datasheet for KISS1 Recombinant Protein (OPCD04677)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Met1-Gly126
::Subcellular Location: Secreted
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 90%
SourceE.coli
TagN-terminal His and GST Tag
Gene SymbolKiss1
Gene Full NameKiSS-1 metastasis-suppressor
Alias Symbols0610012C01Rik;kis;Kiss1 metastasis-suppressor;kisspeptin;kisspeptin-1;meta;metastasis-suppressor KiSS-1;metastatin;metastin.
NCBI Gene Id280287
Protein NameMetastasis-suppressor KiSS-1
Description of TargetMetastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals.
Uniprot IDQ6Y4S4
Protein Accession #NP_839991.2
Nucleotide Accession #NM_178260.3
Protein Size (# AA)Met1~Gly126
Molecular Weight44kDa
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