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Catalog No: OPPA01749 (Formerly GWB-14EBEE)
Size:2UG
Price: $75.00
SKU
OPPA01749
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KISS1 Protein (OPPA01749)

Datasheets/ManualsPrintable datasheet for OPPA01749
Product Info
Predicted Species ReactivityHuman
Product FormatThe protein solution (1mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol. Physical appearance: Sterile Filtered colorless solution.
HostE. Coli
::Product Introduction: KISS1 is a metastasis suppressor protein that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity.KISS1 functions to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. KISS1 is involved in the regulation of cell-matrix adhesion. KISS1 plays a role in cytoskeletal reorganization. A polymorphism in the terminal exon of KISS1 mRNA results in two protein isoforms. Expression of KiSS1 is localized to specific regions of the hypothalamus in numerous species and is regulated by gonadal steroids and across the estrous cycle..KISS1 generates a c-terminally amidated peptide, metastin which functions as the endogenous ligand of the g-protein coupled receptor gpr54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis.
Product Description: KISS1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (20-138) and having a molecular mass of 12.6 Dalton. The KISS1 is purified by proprietary chromatographic techniques.
Reconstitution and StorageKISS1 although stable 4C for 4 weeks, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
PurityGreater than 90.0% as determined by SDS-PAGE.
Peptide SequenceMEPLEKVASV GNSRPTGQQL ESLGLLAPGE QSLPCTERKP AATARLSRRG TSLSPPPESS GSPQQPGLSA PHSRQIPAPQ GAVLVQREKD LPNYNWNSFG LRFGKREAAP GNHGRSAGRG.
Gene SymbolKISS1
Alias SymbolsHH13, KiSS-1
NCBI Gene Id3814
Protein NameMetastasis-suppressor KiSS-1
Description of TargetRecombinant Human KISS-1 Metastasis-Suppressor
Uniprot IDQ15726
Protein Accession #NP_002247.3
Protein Size (# AA)Recombinant
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