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KISS1 Antibody (ARP42026_P050)

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100 ul
$125.00
In Stock
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Conjugation Options

ARP42026_P050-FITC Conjugated

ARP42026_P050-HRP Conjugated

ARP42026_P050-Biotin Conjugated

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Gene Symbol:
KISS1
NCBI Gene Id:
3814
Official Gene Full Name:
KiSS-1 metastasis-suppressor
Protein Name:
Metastasis-suppressor KiSS-1
Swissprot Id:
Q15726
Protein Accession #:
NP_002247
Nucleotide Accession #:
NM_002256
Alias Symbols:
HH13, KiSS-1,
Description of Target:
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
Protein Size (# AA):
138
Molecular Weight:
15 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express KISS1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express KISS1.
Immunogen:
The immunogen is a synthetic peptide directed towards the following sequence SWQLLLFLCATHFGEPLEKVASVGNSRPTGQQLESLGLLAPGEQSLPCTE
Predicted Homology Based on Immunogen Sequence:
Human: 100%
Complete computational species homology data:
Anti-KISS1 (ARP42026_P050)
Peptide Sequence:
Synthetic peptide located within the following region: SWQLLLFLCATHFGEPLEKVASVGNSRPTGQQLESLGLLAPGEQSLPCTE
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
APP; KISS1R; MMP24; MMP16; MMP14; MMP9; MMP2;
Blocking Peptide:
Available upon request
Datasheets/Manuals:
Printable datasheet for anti-KISS1 (ARP42026_P050) antibody
Publications:

Neuropeptide co-expression in hypothalamic kisspeptin neurons of laboratory animals and the human. Front Neurosci. 2015 Feb 10;9:29. Human 25713511

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