KIR2DL4 Antibody (OAEE00101)

Catalog No: OAEE00101

Size:100UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Clonality: Monoclonal
• Clone: mAb#33
• Isotype: IgG1
• Host: Mouse
• Application: Flow cytometry|Immunocytochemistry|Immunoprecipitation|Western blot
• Reconstitution and Storage: 2°C to 8°C
• Immunogen: NK3.3 cells and KIR2DL4-Ig fusion protein
• Purification: Purified
• Concentration: 1 mg/ml
• Specificity: The mouse monoclonal antibody mAb#33 (also known as mAb 33 or 33) recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.
• Formulation: Purified
• Purity: > 95% (by SDS-PAGE)
• Storage Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Reference: LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED: HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells. FASEB J. 2005 Apr;19(6):662-4.
  Yan WH, Fan LA: Residues Met76 and Gln79 in HLA-G alpha1 domain involve in KIR2DL4 recognition. Cell Res. 2005 Mar;15(3):176-82.
  Rajagopalan S, Bryceson YT, Kuppusamy SP, Geraghty DE, van der Meer A, Joosten I, Long EO. Activation of NK cells by an endocytosed receptor for soluble HLA-G. PLoS Biol. 2006 Jan;4(1):e9.
  Goodridge JP, Witt CS, Christiansen FT, Warren HS: KIR2DL4 (CD158d) genotype influences expression and function in NK cells. J Immunol. 2003 Aug 15;171(4):1768-74.
  Rajagopalan S, Fu J, Long EO: Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. J Immunol. 2001 Aug 15;167(4):1877-81.
  

Target Info

• Gene Symbol: KIR2DL4
• Gene Full Name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
• Alias Symbols: CD158 antigen-like family member D;CD158D;G9P;killer cell immunoglobulin-like receptor 2DL4;killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4;killer cell inhibitory receptor 103AS;KIR103;KIR103AS;KIR-103AS;KIR-2DL4;KIR2DL4 Killer-cell Immunoglobulin-like Receptor;KIR2DL4_00201;KIR2DL4_00201 protein;MHC class I NK cell receptor KIR103AS.
• NCBI Gene Id: 3805
• Protein Name: Killer cell immunoglobulin-like receptor 2DL4
• Description of Target: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
• Uniprot ID: Q99706
• Protein Accession #: NP_001074239.1; NP_002246.5
• Nucleotide Accession #: NM_001080770.1; NM_002255.5