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Catalog No: OASE00160 (Formerly GWB-81149A)
Size:100ug
Price: $429.00
SKU
OASE00160
Availability: Discontinued
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Datasheets/ManualsPrintable datasheet for OASE00160
Product Info
Predicted Species ReactivityHuman, Mouse, Rat, Monkey
ClonalityMonoclonal
CloneS112
IsotypeIgG1
HostMouse
ConjugationUnconjugated
ApplicationWB, IHC, ICC, IF, AM
Additional InformationBackground Info: Detects ~45kDa. No cross-reactivity against Kir2.2 or Kir2.3
::Scientific Background: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). The Kir2.1 inward-rectifier potassium ion channel is encoded by the KCNJ2 gene. A defect in this gene is associated with Andersen-Tawil syndrome (3).
::Certificate of Analysis: 1 ug/mL was sufficient for detection of Kir2.1 in 10ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Reconstitution and StorageStore at -20C. Shipping with Blue Ice or 4C.
ImmunogenFusion protein amino acids 41-64 and 189-428 of mouse Kir2.1
PurificationProtein G Purified
Concentration1 mg/ml
SpecificityDetects ~45kDa. No cross-reactivity against Kir2.2 or Kir2.3.
DilutionWB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Storage BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Reference1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA.
2. www.iochannels.org
3. Donaldson M.R., Yoon G., Fu Y.H., Ptacek L.J. (2004).
Ann. Med. 36 Suppl 1: 92–7.
DescriptionThe Kir2.1 inward-rectifier potassium ion channel is encoded by the KCNJ2 gene. A defect in this gene is associated with Andersen-Tawil syndrome (1).
Gene SymbolKir2.1
Gene Full Namepotassium inwardly-rectifying channel, subfamily J, member 2
Alias SymbolsHHBIRK1, HHIRK1, HIRK 1, IRK1, KCNJ2, LQT7, SQT3, potassium inwardly rectifying channel J2
NCBI Gene Id16518
Uniprot IDP35561
Protein Accession #NP_032451
  1. What is the species homology for "Kir2.1 Antibody (OASE00160)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat, Monkey".

  2. How long will it take to receive "Kir2.1 Antibody (OASE00160)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "Kir2.1 Antibody (OASE00160)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Kir2.1 Antibody (OASE00160)"?

    This target may also be called "HHBIRK1, HHIRK1, HIRK 1, IRK1, KCNJ2, LQT7, SQT3, potassium inwardly rectifying channel J2" in publications.

  5. What is the shipping cost for "Kir2.1 Antibody (OASE00160)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Kir2.1 Antibody (OASE00160)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Kir2.1 Antibody (OASE00160)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Kir2.1 Antibody (OASE00160)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "Kir2.1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "Kir2.1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "Kir2.1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "Kir2.1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "Kir2.1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "Kir2.1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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