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- $55: Antibody & Protein in US
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Datasheets/Manuals | Printable datasheet for KDM8 Antibody (OACA05556) (OACA05556) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Unconjugated |
Application | Enzyme-linked immunosorbent assay|Immunohistochemistry |
Reconstitution and Storage | -20°C or -80°C |
Immunogen | Recombinant Human JmjC domain-containing protein 5 protein (151-380AA) |
Purification | Protein G Purified |
Preservative | 0.03% Proclin 300 |
Formulation | 50% Glycerol, 0.01M PBS, PH 7.4 |
Gene Symbol | KDM8 |
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Gene Full Name | lysine demethylase 8 |
Alias Symbols | arginyl C3-hydroxylase KDM8;bifunctional peptidase and arginyl-hydroxylase JMJD5;JmjC arginyl-hydroxylase;jmjC domain-containing protein 5;JMJD5;jumonji C domain-containing protein 5;jumonji domain containing 5;jumonji domain-containing protein 5;L-arginine (3R)-hydroxylase KDM8;lysine (K)-specific demethylase 8;lysine-specific demethylase 8. |
NCBI Gene Id | 79831 |
Protein Name | JmjC domain-containing protein 5 |
Description of Target | Histone demethylase required for G2/M phase cell cycle progression (PubMed:20457893). Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator (PubMed:20457893). Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation (PubMed:20457893). In a complex with coregulator RCCD1, is also able to demethylate trimethylated 'Lys-36' (H3K36me3) of histone H3 (PubMed:24981860). Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1 (PubMed:24981860). Possibly together with RCCD1, involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability (PubMed:28455245). Might function as a protein hydroxylase (PubMed:22851697, PubMed:24100311). Under stress conditions that cause a DNA damage response, acts as a histone protease by cleaving the N-terminal tail of histone H3 at the carboxyl side of monomethyl-lysine (Kme1) residues, preferably at monomethylated 'Lys-9' (H3K9me1) (PubMed:28982940). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). |
Uniprot ID | Q8N371 |
Protein Accession # | NP_001138820 |
Nucleotide Accession # | NM_001145348 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "KDM8 Antibody (OACA05556)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "KDM8 Antibody (OACA05556)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "KDM8 Antibody (OACA05556)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "KDM8 Antibody (OACA05556)"?
This target may also be called "arginyl C3-hydroxylase KDM8;bifunctional peptidase and arginyl-hydroxylase JMJD5;JmjC arginyl-hydroxylase;jmjC domain-containing protein 5;JMJD5;jumonji C domain-containing protein 5;jumonji domain containing 5;jumonji domain-containing protein 5;L-arginine (3R)-hydroxylase KDM8;lysine (K)-specific demethylase 8;lysine-specific demethylase 8." in publications.
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What is the shipping cost for "KDM8 Antibody (OACA05556)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "KDM8 Antibody (OACA05556)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "KDM8 Antibody (OACA05556)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "KDM8 Antibody (OACA05556)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "KDM8"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "KDM8"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "KDM8"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "KDM8"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "KDM8"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "KDM8"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.