KDM3A Antibody (OAEC04708)

Catalog No: OAEC04708

Size:100 ug/100 ul

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Western blot analysis using KDM3A mouse mAb against Hela (1) and HepG2 (2) cell lysate.

Immunohistochemical analysis of paraffin-embedded colonic cancer tissues (left) and lung cancer tissues (right) using KDM3A mouse mAb with DAB staining.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Ascitic fluid containing 0.03% sodium azide
• Clonality: Monoclonal
• Clone: 1E12
• Isotype: IgG1
• Host: Mouse
• Application: WB, IHC
• Reconstitution and Storage: Store at 4C, for long term storage, store at -20C.
• Immunogen: Purified recombinant fragment of human KDM3A expres sed in E. Coli.
• Concentration: 1 mg/ml

Target Info

• Gene Symbol: KDM3A
• Gene Full Name: lysine (K)-specific demethylase 3A
• Alias Symbols: TSGA, JMJD1, JHDM2A, JHMD2A, JMJD1A
• NCBI Gene Id: 55818
• Description of Target: This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- anddimethylation-specific demethylase, binding iron and -ketoglutarate as cofactors anddemethylating Lys ine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.
• Uniprot ID: Q9Y4C1
• Molecular Weight: 147 kDa