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KCTD11 cDNA (ANA10930)

1ug
$189.00
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Gene Symbol:
KCTD11
NCBI Gene Id:
147040
Alias Symbols:
C17orf36, REN, KCASH1, REN/KCTD11
Protein Name:
BTB/POZ domain-containing protein KCTD11
Description of Target:
Play a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
Swissprot Id:
Q693B1
Protein Accession #:
NP_001002914
Nucleotide Accession #:
BC019929
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express KCTD11.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express KCTD11.
Tag:
None
Protein Interactions:
KCTD11; CUL3; HDAC1;
Reconstitution and Storage:
Centrifuge the vials after receiving and add 5 μl ddH2O
Datasheets/Manuals:
Printable datasheet for anti-KCTD11 (ANA10930) antibody

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