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KCTD11 cDNA (ANA10930)

Catalog#: ANA10930
Domestic: within 24 hours delivery | International: 3-5 business days
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Reconstitution and Storage Centrifuge the vials after receiving and add 5 μl ddH2O
Tag None
Datasheets/Manuals Printable datasheet for anti-KCTD11 (ANA10930) antibody
Gene Symbol KCTD11
Alias Symbols C17orf36, REN, KCASH1, REN/KCTD11
NCBI Gene Id 147040
Protein Name BTB/POZ domain-containing protein KCTD11
Description of Target Play a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
Swissprot Id Q693B1
Protein Accession # NP_001002914
Nucleotide Accession # BC019929
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express KCTD11.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express KCTD11.
Protein Interactions KCTD11; CUL3; HDAC1;
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