KCNQ3 Antibody (Phospho-Thr246) (OAAF00246)

Catalog No: OAAF00246 (Formerly GWB-ASB515)

Size:100 ug

Immunohistochemistry analysis of paraffin-embedded human brain, using Kv7.3/KCNQ3 (Phospho-Thr246) Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: Kv7.3/KCNQ3 (Phospho-Thr246) antibody detects endogenous levels of Kv7.3/KCNQ3 only when phosphorylated at threonine 246.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB:1：500~1：3000; IHC: 1:50~1:100; ELISA: 1:20000
• Reference: Schroeder B.C., Nature 396:687-690(1998).
  Charlier C., Nat. Genet. 18:53-55(1998).
  Yang W.-P., J. Biol. Chem. 273:19419-19423(1998).
• Publications:

  Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflugers Arch. 470, 1359-1376 (2018). 29797067

• Description:
  View product citations for KCNQ3 Antibody (Phospho-Thr246) (OAAF00246) on CiteAb

Target Info

• Gene Symbol: KCNQ2|KCNQ3|KCNQ4|KCNQ5
• Gene Full Name: potassium voltage-gated channel subfamily Q member 2|potassium voltage-gated channel subfamily Q member 3|potassium voltage-gated channel subfamily Q member 4|potassium voltage-gated channel subfamily Q member 5
• Alias Symbols: BFNC;BFNC2;DEE7;DFNA2;DFNA2A;EBN;EBN1;EBN2;ENB1;HNSPC;KCNA11;KQT-like 2;KQT-like 3;KQT-like 4;KQT-like 5;KV7.2;KV7.3;KV7.4;Kv7.5;MRD46;neuroblastoma-specific potassium channel subunit alpha KvLQT2;potassium channel KQT-like 4;potassium channel protein;potassium channel subunit alpha KvLQT3;potassium channel subunit alpha KvLQT4;potassium channel subunit alpha KvLQT5;potassium channel, voltage gated KQT-like subfamily Q, member 2;potassium channel, voltage gated KQT-like subfamily Q, member 3;potassium channel, voltage gated KQT-like subfamily Q, member 4;potassium channel, voltage gated KQT-like subfamily Q, member 5;potassium channel, voltage-gated, subfamily Q, member 3;potassium voltage-gated channel subfamily KQT member 2;potassium voltage-gated channel subfamily KQT member 3;potassium voltage-gated channel subfamily KQT member 4;potassium voltage-gated channel subfamily KQT member 5;potassium voltage-gated channel, KQT-like subfamily, member 3;potassium voltage-gated channel, KQT-like subfamily, member 4;voltage-gated potassium channel subunit Kv7.2;voltage-gated potassium channel subunit Kv7.3;Voltage-gated potassium channel subunit Kv7.4;voltage-gated potassium channel subunit Kv7.5.
• NCBI Gene Id: 3785|3786|56479|9132
• Protein Name: Potassium voltage-gated channel subfamily KQT member 2|Potassium voltage-gated channel subfamily KQT member 3|Potassium voltage-gated channel subfamily KQT member 4|Potassium voltage-gated channel subfamily KQT member 5
• Description of Target: Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.|Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.|Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873).|Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
• Uniprot ID: O43525|O43526|P56696|Q9NR82
• Protein Accession #: NP_001191753.1
• Molecular Weight: 96 kDa