Size:100 ul
$249.00
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ARP35459_T100-FITC
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Conjugation Options

ARP35459_T100 Unconjugated

ARP35459_T100-HRP Conjugated

ARP35459_T100-Biotin Conjugated

KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC)

Catalog#: ARP35459_T100-FITC
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Predicted Species ReactivityCow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer.
ClonalityPolyclonal
HostRabbit
ConjugationFITC (FAM): Excitation 495 nm/ Emission 520 nm
ApplicationIHC, WB
Reconstitution and StorageAll conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Replacement ItemThis antibody may replace item sc-128912 from Santa Cruz Biotechnology.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human KCNQ2
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%
Complete computational species homology dataAnti-KCNQ2 (ARP35459_T100)
Peptide SequenceSynthetic peptide located within the following region: GNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYI
Concentration0.5 mg/ml
Blocking PeptideFor anti-KCNQ2 (ARP35459_T100-FITC) antibody is Catalog # AAP35459 (Previous Catalog # AAPP07278)
Datasheets/ManualsPrintable datasheet for anti-KCNQ2 (ARP35459_T100-FITC) antibody
Target ReferenceTang,B., et al., (2004) J. Neurol. Sci. 221 (1-2), 31-34
Publications

Zhang, H. et al. Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents. Neuroscience 254, 70-9 (2013). WB, Human, Mouse, Rat, Bovine, Dog, Horse, Guinea pig, Zebrafish, Rabbit 24036375

Gene SymbolKCNQ2
Official Gene Full NamePotassium voltage-gated channel, KQT-like subfamily, member 2
Alias SymbolsEBN, BFNC, EBN1, ENB1, BFNS1, EIEE7, HNSPC, KV7.2, KCNA11, KVEBN1
NCBI Gene Id3785
Description of TargetThe M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).
Swissprot IdQ5VYU0
Protein Accession #NP_742107
Nucleotide Accession #NM_172109
Protein Size (# AA)393
Molecular Weight43kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express KCNQ2.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express KCNQ2.
Protein InteractionsARIH2; KCNQ3; PRKCA; CALM3; CALM1; CALM2; KCNQ1;
  1. What is the species homology for "KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish".

  2. How long will it take to receive "KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC)"?

    This target may also be called "EBN, BFNC, EBN1, ENB1, BFNS1, EIEE7, HNSPC, KV7.2, KCNA11, KVEBN1" in publications.

  5. What is the shipping cost for "KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC)"?

    All Aviva products have been through vigorous validations and carry 100% satisfaction warranty.

  7. Can I get bulk pricing for "KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "43kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "KCNQ2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "KCNQ2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "KCNQ2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "KCNQ2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "KCNQ2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "KCNQ2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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