- Gene Symbol:
- KCNQ2
- NCBI Gene Id:
- 3785
- Official Gene Full Name:
- Potassium voltage-gated channel, KQT-like subfamily, member 2
- Swissprot Id:
- Q5VYU0
- Protein Accession #:
- NP_742107
- Nucleotide Accession #:
- NM_172109
- Alias Symbols:
- EBN, BFNC, EBN1, ENB1, BFNS1, EIEE7, HNSPC, KV7.2, KCNA11, KVEBN1
- Replacement Item:
- This antibody may replace item sc-128912 from Santa Cruz Biotechnology.
- Description of Target:
- The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).
- Protein Size (# AA):
- 393
- Molecular Weight:
- 43kDa
- Host:
- Rabbit
- Clonality:
- Polyclonal
- Purification:
- Protein A purified
- Application:
- IHC, WB
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express KCNQ2.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express KCNQ2.
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human KCNQ2
- Tested Species Reactivity:
- Human, Mouse
- Predicted Homology Based on Immunogen Sequence:
- Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%
- Complete computational species homology data:
- Anti-KCNQ2 (ARP35459_T100)
- Peptide Sequence:
- Synthetic peptide located within the following region: GNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYI
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Concentration:
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Protein Interactions:
- ARIH2; KCNQ3; PRKCA; CALM3; CALM1; CALM2; KCNQ1;
- Blocking Peptide:
- For anti-KCNQ2 (ARP35459_T100) antibody is Catalog # AAP35459 (Previous Catalog # AAPP07278)
- Datasheets/Manuals:
- Printable datasheet for anti-KCNQ2 (ARP35459_T100) antibody
- Target Reference:
- Tang,B., et al., (2004) J. Neurol. Sci. 221 (1-2), 31-34
- Publications:
Zhang, H. et al. Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents. Neuroscience 254, 70-9 (2013). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 24036375
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