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KCNQ2 Antibody - middle region (ARP35459_T100)

100 ul
$249.00
In Stock
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Conjugation Options

ARP35459_T100-FITC Conjugated

ARP35459_T100-HRP Conjugated

ARP35459_T100-Biotin Conjugated

Gene Symbol:
KCNQ2
Official Gene Full Name:
Potassium voltage-gated channel, KQT-like subfamily, member 2
NCBI Gene Id:
3785
Swissprot Id:
Q5VYU0
Protein Accession #:
NP_742107
Nucleotide Accession #:
NM_172109
Alias Symbols:
EBN, BFNC, EBN1, ENB1, BFNS1, EIEE7, HNSPC, KV7.2, KCNA11, KVEBN1
Replacement Item:
This antibody may replace item sc-128912 from Santa Cruz Biotechnology.
Description of Target:
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).
Protein Size (# AA):
393
Molecular Weight:
43kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express KCNQ2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express KCNQ2.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human KCNQ2
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Tested Species Reactivity:
Human, Mouse
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%
Complete computational species homology data:
Anti-KCNQ2 (ARP35459_T100)
Peptide Sequence:
Synthetic peptide located within the following region: GNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYI
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
ARIH2; KCNQ3; PRKCA; CALM3; CALM1; CALM2; KCNQ1;
Blocking Peptide:
For anti-KCNQ2 (ARP35459_T100) antibody is Catalog # AAP35459 (Previous Catalog # AAPP07278)
Datasheets/Manuals:
Printable datasheet for anti-KCNQ2 (ARP35459_T100) antibody
Target Reference:
Tang,B., et al., (2004) J. Neurol. Sci. 221 (1-2), 31-34
Publications:

Zhang, H. et al. Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents. Neuroscience 254, 70-9 (2013). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 24036375

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