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KChiP3 Antibody (OASE00219)

  • Catalog#: OASE00219
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100ug
$350.00
Discontinued
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Conjugation Options

OASE00219-FITC Conjugated

OASE00219-HRP Conjugated

OASE00219-Biotin Conjugated

Gene Symbol:
Kcnip3
NCBI Gene Id:
65199
Official Gene Full Name:
Kv channel interacting protein 3, calsenilin
Swissprot Id:
Q9JM47
Protein Accession #:
NP_115851.1
Replacement Item:
This antibody may replace item sc-111016 from Santa Cruz Biotechnology.
Host:
Mouse
Clonality:
Monoclonal
Purification:
Protein G Purified
Application:
WB, IHC, IP
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express Kcnip3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express Kcnip3.
Immunogen:
Fusion protein amino acids 1-256 (Full length) of rat Calsenillin/DREAM/KChIP3
Predicted Species Reactivity:
Human, Mouse, Rat
Reconstitution and Storage:
Store at -20C. Shipping in Blue Ice or 4C.
Concentration:
1mg/mL
Datasheets/Manuals:
Printable datasheet for OASE00219
Dilution:
1ug/mL (WB), 0.1-1ug/mL (IHC/ICC), 1-10ug/mL (IF)
Clone:
S66-38
Isotype:
IgG2a
Additional Information:
Background Info: Detects ~34kDa. No cross reactivity against KCIPs 1,2 or 4
:::
Scientific Background: There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF hand containing
proteins required for the traffic of channel forming
Kv4 K+ subunits to the plasma membrane (3).
KChiP3 is also known as calsenilin and as the transcription
factor, downstream regulatory element antagonist
modulator (DREAM), which regulates a number of genes
including prodynorphon. They are highly expressed in the
hippocampus. Through its various functions, it may play a
role in the regulation of synaptic plasticity, learning and
memory (4).
:::
Certificate of Analysis: 1 ug/mL was sufficient for detection of KChIP3 in 20ug of mouse brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Storage Buffer:
PBS pH7.4, 50% glycerol
Target Reference:
1. Hille B. (2001) Ion Channels of Excitable
Membranes, 3rd Ed., Sinauer Associated Inc.:
Sunderland, MA USA.
2. www.iochannels.org
3. Flowerdew S.E., and Burgoyne R.D. (2009) Biochem
J. 418(3): 529-540.
4. Alexander J.C., et al. (2009) Learn Mem. 16(3): 167-
177.

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