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KChIP3 Antibody - N-terminal region (Phospho-M1) (OAAB11394)

400ul
$390.00
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Gene Symbol:
KCNIP3
NCBI Gene Id:
30818
Protein Name:
Calsenilin
Swissprot Id:
Q9Y2W7
Protein Accession #:
NP_001030086.1
Alias Symbols:
KCNIP3, CSEN, DREAM, KCHIP3, Calsenilin, A-type potassium channel modulatory protein 3, DRE-antagonist modulator, Kv channel-interacting protein 3
Replacement Item:
This antibody may replace item sc-111016 from Santa Cruz Biotechnology.
Description of Target:
KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.
Molecular Weight:
29 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Application:
WB, IHC-P, IF, ELISA
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express KCNIP3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express KCNIP3.
Immunogen:
This KChIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KChIP3.
Predicted Species Reactivity:
Human, Mouse
Product Format:
Liquid. PBS with 0.09% (W/V) sodium azide.
Reconstitution and Storage:
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Concentration:
1.8 mg/ml
Datasheets/Manuals:
Printable datasheet for OAAB11394
Isotype:
Ig
Intended Use:
KChIP3 Antibody (N-term M1) is for research use only and not for use in diagnostic or therapeutic procedures.
Application Info:
WB: 1:1000
IHC-P: 1:50~100
IF: 1:10~50
Additional Information:
Cellular Location: Cytoplasm. Cell membrane; Lipid-anchor Endoplasmic reticulum. Golgi apparatus. Nucleus Note=Also membrane-bound, associated with the plasma membrane. In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
Tissue Location: Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.

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