KAT5 Antibody (OAAF00963)

Catalog No: OAAF00963 (Formerly GWB-ASC372)

Size:100 ug

Click here to learn more about Aviva's By-Request Conjugation Service.

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using TIP60 Antibody. The picture on the right is treated with the synthesized peptide.

Immunofluorescence analysis of HeLa cells, using TIP60 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human TIP60.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: TIP60 antibody detects endogenous levels of total TIP60 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:1000
• Reference: Kamine J., Virology 216:357-366(1996).
  Sheridan A.M., Mol. Cell. Biol. 21:4470-4481(2001).
  Legube G., Gene 310:161-168(2003).

Target Info

• Gene Symbol: KAT5
• Gene Full Name: lysine acetyltransferase 5
• Alias Symbols: 60 kDa Tat-interactive protein;cPLA(2)-interacting protein;cPLA2;cPLA2 interacting protein;ESA1;histone acetyltransferase HTATIP;histone acetyltransferase KAT5;HIV-1 Tat interactive protein, 60kDa;HTATIP;HTATIP1;K(lysine) acetyltransferase 5;K-acetyltransferase 5;Lysine acetyltransferase 5;NEDFASB;PLIP;Tat interacting protein, 60kDa;TIP;TIP60;ZC2HC5.
• NCBI Gene Id: 10524
• Protein Name: Histone acetyltransferase KAT5
• Description of Target: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565). Acetylates RAN at 'Lys-134' (PubMed:29040603).
• Uniprot ID: Q92993
• Protein Accession #: NP_001193762.1
• Molecular Weight: 58 kDa