KAT5 Antibody - C-terminal (OAPB01755)

Catalog No: OAPB01755

Size:100UG

Western blot analysis of KAT5 in human brain tissue lysate with KAT5 antibody at 1 ug/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. KAT5 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: KAT5 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KAT5. The immunogen is located within the last 50 amino acids of KAT5.
• Purification: Affinity Purified
• Concentration: 1 mg/ml

Target Info

• Gene Symbol: KAT5
• Gene Full Name: lysine acetyltransferase 5
• Alias Symbols: 60 kDa Tat-interactive protein;cPLA(2)-interacting protein;cPLA2;cPLA2 interacting protein;ESA1;histone acetyltransferase HTATIP;histone acetyltransferase KAT5;HIV-1 Tat interactive protein, 60kDa;HTATIP;HTATIP1;K(lysine) acetyltransferase 5;K-acetyltransferase 5;Lysine acetyltransferase 5;NEDFASB;PLIP;Tat interacting protein, 60kDa;TIP;TIP60;ZC2HC5.
• NCBI Gene Id: 10524
• Protein Name: Histone acetyltransferase KAT5|histone acetyltransferase KAT5 isoform 1 [Homo sapiens]
• Description of Target: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565). Acetylates RAN at 'Lys-134' (PubMed:29040603).
• Uniprot ID: Q92993
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_874369
• Nucleotide Accession #: NM_001206833.1
• Molecular Weight: Predicted: 51, 54, 56, 60 kDa Observed: 53 kDa