JPH3 Antibody (OAPB00793)

Catalog No: OAPB00793

Size:100UG

Western blot analysis of JPH3 in Daudi cell lysate with JPH3 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Immunohistochemistry of JPH3 in human brain tissue with JPH3 antibody at 2.5 ug/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. JPH3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Source:
  Rabbit polyclonal JPH3 antibody was raised against an 18 amino acid peptide near the center of human JPH3 (GenBank accession no. NP_065706).
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: JPH3 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: JPH3 antibody was raised against a 18 amino acid synthetic peptide near the center of human JPH3. The immunogen is located within amino acids 410 - 460 of JPH3.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-JPH3 antibody is Catalog # OEPB02913
• Application Info: JPH3 antibody can be used for detection of JPH3 by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)
• Reference: Takeshima H, Komazaki S, Nishi M, et al. Junctophilins: a novel family of junctional membrane complex proteins. Mol. Cell.2000; 6:11-22.;Kakizawa S, Kishimoto Y, Hashimoto K, et al. Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. EMBO J.2007; 26:1924-33.;Nishi M, Sakagami H, Komazaki S, et al. Coexpression of junctophilin type 3 and type 4 in brain. Brain Res. Mol. Brain Res.2003; 118:102-10.;Moriguchi S, Nishi M, Komazaki S, et al. Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. Proc. Natl. Acad. Sci.2006; 103:10811-6.

Target Info

• Gene Symbol: JPH3
• Gene Full Name: junctophilin 3
• Alias Symbols: CAGL237;HDL2;JP3;JP-3;junctophilin type 3;junctophilin-3;TNRC22;trinucleotide repeat containing 22;Trinucleotide repeat-containing gene 22 protein.
• NCBI Gene Id: 57338
• Protein Name: Junctophilin-3|junctophilin-3 isoform 1 [Homo sapiens]
• Description of Target: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.
• Uniprot ID: Q8WXH2
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_065706