Size:100 ul
Special Price $229.00 Regular Price $319.00
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SKU
ARP40101_P050
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Conjugation Options

ARP40101_P050-FITC Conjugated

ARP40101_P050-HRP Conjugated

ARP40101_P050-Biotin Conjugated

JMJD3 Antibody - N-terminal region (ARP40101_P050)

Catalog#: ARP40101_P050
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More Information
Tested Species ReactivityHuman
Predicted Species ReactivityCow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human JMJD3
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%
Complete computational species homology dataAnti-JMJD3 (ARP40101_P050)
Peptide SequenceSynthetic peptide located within the following region: HRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASI
ConcentrationBatch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking PeptideFor anti-KDM6B (ARP40101_P050) antibody is Catalog # AAP40101 (Previous Catalog # AAPP22939)
Datasheets/ManualsPrintable datasheet for anti-KDM6B (ARP40101_P050) antibody
Target ReferenceHong,S., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (47), 18439-18444
Gene SymbolKDM6B
Official Gene Full NameLysine (K)-specific demethylase 6B
Alias SymbolsKIAA0346, JMJD3
NCBI Gene Id23135
Protein NameLysine-specific demethylase 6B
Description of TargetJMJD3 is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
Swissprot IdO15054
Protein Accession #NP_001073893
Nucleotide Accession #NM_001080424
Protein Size (# AA)1682
Molecular Weight181kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express JMJD3.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express JMJD3.
Protein InteractionsWDR5; ASH2L; RBBP5; UBC; TK1; CSNK2B; HIST1H3A; WAS; SMAD3; SMAD2; SMAD4; SMAD1;
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