ITLN1 Antibody (OAED00377)

Catalog No: OAED00377

Size:100 ug

Figure: Immunohistochemical staining of endogenous human Omentin 1 in different human tissues (paraffin sections) using MAb to Omentin 1 (Saly-1). Method: Different human normal tissues (A: Rectum; B: Small Intestine; C: Stomach) or cancer tissues (D: Colorectal cancer) were stained with MAb to Omentin 1 (Saly-1) by standard immunohistochemistry. Pictures courtesy of Human Protein Atlas (www.proteinatlas.org).

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: Saly-1
• Isotype: IgG2b
• Host: Mouse
• Application: IHC, WB
• Reconstitution and Storage: Long Term Storage : -20C
  Short Term Storage : +4C
  Handling : After opening, prepare aliquots and store at -20C.
  Avoid freeze/thaw cycles
  Stable for at least 1 year after receipt when stored at -20C.
• Immunogen: Recombinant human omentin 1 (intelectin-1) (aa 17-231).
• Concentration: 1mg/ml
• Specificity: Recognizes human omentin 1.
• Source: Purified from concentrated hybridoma tissue cell culture supernatant.
• Formulation: Liquid. In PBS containing 0.02% sodium azide.
• Purity: Protein G-affinity purified.
  ≥95% (SDS-PAGE)
• Application Info: ELISA (capture)
  Immunohistochemistry (paraffin sections)
  Western Blot (1:1,000)
• Reference: Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 801 (2008), Abstract;
  Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006), Abstract;

Target Info

• Gene Symbol: ITLN1
• Gene Full Name: Intelectin-1
• Alias Symbols: HL1, LFR, HL-1, INTL, ITLN, hIntL, omentin
• NCBI Gene Id: 55600
• Protein Name: Intelectin-1
• Description of Target: Omentin 1 (also named intelectin-1, endothelial lectin HL-1 and intestinal lactoferrin receptor) has been identified as a visceral fat (or omental fat) depot-specific adipokine. Omentin 1 is a secreted protein of ~38 kDa containing a fibrinogen-related domain. Omentin 1 is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin.
• Uniprot ID: Q8WWA0
• Protein Accession #: NP_060095.2
• Nucleotide Accession #: NM_017625.2