ITGB3BP Antibody - N-terminal region : FITC (ARP54999_P050-FITC)

Catalog No: ARP54999_P050-FITC

Size:100ul

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ITGB3BP
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%
• Peptide Sequence: Synthetic peptide located within the following region: TGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ITGB3BP (ARP54999_P050-FITC) antibody is Catalog # AAP54999 (Previous Catalog # AAPP32260)

Target Info

• Reference: Gregory,S.G., (2006) Nature 441 (7091), 315-321
• Gene Symbol: ITGB3BP
• Gene Full Name: Integrin beta 3 binding protein (beta3-endonexin)
• Alias Symbols: CENPR, NRIF3, TAP20, CENP-R, HSU37139
• NCBI Gene Id: 23421
• Protein Name: Centromere protein R
• Description of Target: ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
• Uniprot ID: Q13352
• Protein Accession #: NP_055103
• Nucleotide Accession #: NM_014288
• Protein Size (# AA): 177
• Molecular Weight: 20kDa
• Protein Interactions: PIH1D2; UBR7; ARFIP2; COL4A3BP; KIFC3; KDM1A; UBC; APP; CENPP; CENPO; SVIL; MAPK6; ACTN2; MTA1; ITGB3BP; DDX24; RECQL5; RXRA; ITGB3; NFKB1; ITGB5; ESR1; CCNA2; THRA; RELA; RXRG;