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Datasheets/Manuals | Printable datasheet for anti-ITGB3BP (ARP54999_P050) antibody |
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Tested Species Reactivity | Human |
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Predicted Species Reactivity | Human |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human ITGB3BP |
Purification | Affinity Purified |
Predicted Homology Based on Immunogen Sequence | Human: 100% |
Peptide Sequence | Synthetic peptide located within the following region: TGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDE |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-ITGB3BP (ARP54999_P050) antibody is Catalog # AAP54999 (Previous Catalog # AAPP32260) |
Reference | Gregory,S.G., (2006) Nature 441 (7091), 315-321 |
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Gene Symbol | ITGB3BP |
Gene Full Name | Integrin beta 3 binding protein (beta3-endonexin) |
Alias Symbols | CENPR, NRIF3, TAP20, CENP-R, HSU37139 |
NCBI Gene Id | 23421 |
Protein Name | Centromere protein R |
Description of Target | ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. |
Uniprot ID | Q13352 |
Protein Accession # | NP_055103 |
Nucleotide Accession # | NM_014288 |
Protein Size (# AA) | 177 |
Molecular Weight | 20kDa |
Protein Interactions | PIH1D2; UBR7; ARFIP2; COL4A3BP; KIFC3; KDM1A; UBC; APP; CENPP; CENPO; SVIL; MAPK6; ACTN2; MTA1; ITGB3BP; DDX24; RECQL5; RXRA; ITGB3; NFKB1; ITGB5; ESR1; CCNA2; THRA; RELA; RXRG; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "ITGB3BP Antibody - N-terminal region (ARP54999_P050)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".
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How long will it take to receive "ITGB3BP Antibody - N-terminal region (ARP54999_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "ITGB3BP Antibody - N-terminal region (ARP54999_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "ITGB3BP Antibody - N-terminal region (ARP54999_P050)"?
This target may also be called "CENPR, NRIF3, TAP20, CENP-R, HSU37139" in publications.
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What is the shipping cost for "ITGB3BP Antibody - N-terminal region (ARP54999_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "ITGB3BP Antibody - N-terminal region (ARP54999_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "ITGB3BP Antibody - N-terminal region (ARP54999_P050)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "20kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "ITGB3BP Antibody - N-terminal region (ARP54999_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "ITGB3BP"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "ITGB3BP"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "ITGB3BP"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "ITGB3BP"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "ITGB3BP"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "ITGB3BP"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.