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ITGB3 Antibody (OABF00123)

100 ul
$359.00
In Stock
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Conjugation Options

OABF00123-FITC Conjugated

OABF00123-HRP Conjugated

OABF00123-Biotin Conjugated

Predicted Species Reactivity:
Human, Mouse
Product Format:
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Conjugation:
Unconjugated
Application:
WB, FC, IHC-P, ICC
Additional Information:
Subcellular location: Extracellular
Reconstitution and Storage:
Store at -20C for 12 months.
Gene Symbol:
ITGB3
Official Gene Full Name:
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
NCBI Gene Id:
3690
Swissprot Id:
P05106
Alias Symbols:
GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16,
Replacement Item:
This antibody may replace item sc-13579 from Santa Cruz Biotechnology.
Description of Target:
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Purification:
Purified by Protein A.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ITGB3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ITGB3.
Immunogen:
KLH conjugated synthetic peptide derived from human Integrin beta 3
Concentration:
1ug/ul
Datasheets/Manuals:
Printable datasheet for OABF00123
Application Info:
WB: 1:100 - 1000
ELISA: 1:500 - 1000
FC: 1:20 - 100
IHC-P: : 1:100 - 500

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