Size:400ul
$329.00
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SKU
OAAB05267
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ITGB3 Antibody - C-terminal region (OAAB05267)

Catalog#: OAAB05267
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species Reactivity Human, Mouse
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality Polyclonal
Isotype Rabbit Ig
Host Rabbit
Application WB, FC, IHC
Additional Information Function: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
:: Cellular Location: Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesion
Tissue Location: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-13579 from Santa Cruz Biotechnology.
Immunogen This ITGB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 734-760 amino acids from the C-terminal region of human ITGB3.
Predicted Homology Based on Immunogen Sequence Human; Mouse
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals Printable datasheet for anti-ITGB3 antibody - OAAB05267
Application Info WB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50
Other Applications Image 1 Data ITGB3 Antibody (C-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Gene Symbol ITGB3
Alias Symbols Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD_antigen=CD61, Flags: Precursor, GP3A, ITGB3
NCBI Gene Id 3690
Protein Name Integrin beta-3
Swissprot Id P05106
Protein Accession # NP_000203.2
Molecular Weight 87058 Da
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express ITGB3.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express ITGB3.
  1. What is the species homology for "ITGB3 Antibody - C-terminal region (OAAB05267)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".

  2. How long will it take to receive "ITGB3 Antibody - C-terminal region (OAAB05267)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "ITGB3 Antibody - C-terminal region (OAAB05267)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ITGB3 Antibody - C-terminal region (OAAB05267)"?

    This target may also be called "Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD_antigen=CD61, Flags: Precursor, GP3A, ITGB3" in publications.

  5. What is the shipping cost for "ITGB3 Antibody - C-terminal region (OAAB05267)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ITGB3 Antibody - C-terminal region (OAAB05267)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ITGB3 Antibody - C-terminal region (OAAB05267)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "87058 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ITGB3 Antibody - C-terminal region (OAAB05267)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "ITGB3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ITGB3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ITGB3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ITGB3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ITGB3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ITGB3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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