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ITGB3 Antibody - C-terminal region (OAAB05267)

400ul
$390.00
In Stock
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Predicted Species Reactivity:
Human, Mouse
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Host:
Rabbit
Application:
WB, FC, IHC
Additional Information:
Function: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
:::
Cellular Location: Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesion
Tissue Location: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
ITGB3
NCBI Gene Id:
3690
Protein Name:
Integrin beta-3
Swissprot Id:
P05106
Protein Accession #:
NP_000203.2
Alias Symbols:
Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD_antigen=CD61, Flags: Precursor, GP3A, ITGB3
Replacement Item:
This antibody may replace item sc-13579 from Santa Cruz Biotechnology.
Molecular Weight:
87058 Da
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ITGB3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ITGB3.
Immunogen:
This ITGB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 734-760 amino acids from the C-terminal region of human ITGB3.
Predicted Homology Based on Immunogen Sequence:
Human; Mouse
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for anti-ITGB3 antibody - OAAB05267
Application Info:
WB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50
Other Applications Image 1 Data:
ITGB3 Antibody (C-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

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