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Catalog No: OAEE00071
Size:100UG
Price: $199.00
SKU
OAEE00071
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for ITGAM Antibody (OAEE00071) (OAEE00071)
Product Info
Predicted Species ReactivityHuman
Product FormatPhosphate buffered saline (PBS), pH 7.4
ClonalityMonoclonal
CloneMEM-170
IsotypeIgG1
HostMouse
ApplicationFlow cytometry|Functional assay
Reconstitution and Storage2°C to 8°C
ImmunogenHuman granulocytes
PurificationPurified
Concentration1 mg/ml
SpecificityThe antibody MEM-170 recognizes CD11b antigen (Mac-1alpha), a 165-170 kDa transmembrane protein type 1 mainly expressed on monocytes, granulocytes and NK-cells. The antibody blocks (not completely) Mac-1-mediated neutrophil binding to fibrinogen.
HLDA VI., WS Code A054
FormulationAzide free
Purity> 95% (by SDS-PAGE)
Storage BufferAzide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized.
ReferenceLeukocyte Typing VI. Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).
Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E.: Effects of beta-glucans on the immune system. Medicina (Kaunas). 2007;43(8):597-606.
Lawrence PK, Srikumaran S.: CD11b of Ovis canadensis and Ovis aries: molecular cloning and characterization.Vet Immunol Immunopathol. 2007 Oct 15;119(3-4):287-98.
Hentzen ER, Neelamegham S, Kansas GS, Benanti JA, McIntire LV, Smith CW, Simon SI. Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1. Blood. 2000 Feb 1;95(3):911-20.
Gene SymbolITGAM
Gene Full Nameintegrin subunit alpha M
Alias Symbolsantigen CD11b (p170);CD11 antigen-like family member B;CD11B;cell surface glycoprotein MAC-1 subunit alpha;complement component 3 receptor 3 subunit;CR-3 alpha chain;CR3A;integrin alpha-M;integrin, alpha M (complement component 3 receptor 3 subunit);leukocyte adhesion receptor MO1;MAC-1;MAC1A;macrophage antigen alpha polypeptide;macrophage-1 antigen alpha subunit;MO1A;Neutrophil adherence receptor;neutrophil adherence receptor alpha-M subunit;SLEB6.
NCBI Gene Id3684
Protein NameIntegrin alpha-M
Description of TargetIntegrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).
Uniprot IDP11215
Protein Accession #NP_000623.2; NP_001139280.1
Nucleotide Accession #NM_000632.3; NM_001145808.1
  1. What is the species homology for "ITGAM Antibody (OAEE00071)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "ITGAM Antibody (OAEE00071)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "ITGAM Antibody (OAEE00071)" provided in?

    This item is provided in "Phosphate buffered saline (PBS), pH 7.4".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ITGAM Antibody (OAEE00071)"?

    This target may also be called "antigen CD11b (p170);CD11 antigen-like family member B;CD11B;cell surface glycoprotein MAC-1 subunit alpha;complement component 3 receptor 3 subunit;CR-3 alpha chain;CR3A;integrin alpha-M;integrin, alpha M (complement component 3 receptor 3 subunit);leukocyte adhesion receptor MO1;MAC-1;MAC1A;macrophage antigen alpha polypeptide;macrophage-1 antigen alpha subunit;MO1A;Neutrophil adherence receptor;neutrophil adherence receptor alpha-M subunit;SLEB6." in publications.

  5. What is the shipping cost for "ITGAM Antibody (OAEE00071)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ITGAM Antibody (OAEE00071)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ITGAM Antibody (OAEE00071)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ITGAM Antibody (OAEE00071)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ITGAM"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ITGAM"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ITGAM"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ITGAM"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ITGAM"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ITGAM"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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