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Datasheets/Manuals | Printable datasheet for ITGA2B Antibody (OAEE00233) (OAEE00233) |
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Predicted Species Reactivity | Mouse |
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Product Format | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Clonality | Monoclonal |
Clone | MWReg30 |
Isotype | IgG1 |
Host | Rat |
Application | Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Immunoprecipitation |
Reconstitution and Storage | 2°C to 8°C |
Immunogen | Murine platelets |
Purification | Purified |
Concentration | 1 mg/ml |
Specificity | The rat monoclonal antibody MWReg30 recognizes CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes. |
Formulation | Purified |
Purity | > 95% (by SDS-PAGE) |
Storage Buffer | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
Reference | Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX: Stress-induced hematopoietic failure in the absence of immediate early response gene X-1. Haematologica. 2013 Sep 20. [Epub ahead of print] Sullivan BP, Wang R, Tawfik O, Luyendyk JP: Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol Sci. 2010 May;115(1):286-94. Boisset JC, Clapes T, Van Der Linden R, Dzierzak E, Robin C: Integrin alphaIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open. 2013 Apr 11;2(5):525-32. Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M: A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. Blood. 2013 Jul 25;122(4):608-17. |
Gene Symbol | Itga2b |
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Gene Full Name | integrin alpha 2b |
Alias Symbols | AI172977;al;alpha IIb;alphaIIb;CD41;CD41B;Gp;GP IIb;GPalpha IIb;GpIIb;integrin alpha-IIb;platelet glycoprotein IIb of IIb/II Ia complex;platelet membrane glycoprotein IIb. |
NCBI Gene Id | 16399 |
Protein Name | Integrin alpha-IIb |
Description of Target | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
Uniprot ID | Q9QUM0 |
Protein Accession # | NP_000410.2 |
Nucleotide Accession # | NM_000419.3 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "ITGA2B Antibody (OAEE00233)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Mouse".
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How long will it take to receive "ITGA2B Antibody (OAEE00233)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
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What buffer format is "ITGA2B Antibody (OAEE00233)" provided in?
This item is provided in "Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "ITGA2B Antibody (OAEE00233)"?
This target may also be called "AI172977;al;alpha IIb;alphaIIb;CD41;CD41B;Gp;GP IIb;GPalpha IIb;GpIIb;integrin alpha-IIb;platelet glycoprotein IIb of IIb/II Ia complex;platelet membrane glycoprotein IIb." in publications.
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What is the shipping cost for "ITGA2B Antibody (OAEE00233)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "ITGA2B Antibody (OAEE00233)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "ITGA2B Antibody (OAEE00233)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "ITGA2B Antibody (OAEE00233)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "Itga2b"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "Itga2b"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "Itga2b"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "Itga2b"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "Itga2b"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "Itga2b"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.