Catalog No: OAEE00231
Size:100UG
Price: $199.00
SKU
OAEE00231
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for ITGA2B Antibody (OAEE00231) (OAEE00231)
Product Info
Predicted Species ReactivityHuman
Product FormatPhosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
ClonalityMonoclonal
CloneMEM-06
IsotypeIgG1
HostMouse
ApplicationFlow cytometry
Reconstitution and Storage2°C to 8°C
ImmunogenLeukocytes of patient suffering from LGL-type leukaemia.
PurificationPurified
Concentration1 mg/ml
SpecificityThe antibody MEM-06 reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
FormulationPurified
Purity> 95% (by SDS-PAGE)
Storage BufferPhosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
ReferenceDebili N, Robin C, Schiavon V, Letestu R, Pflumio F, Mitjavila-Garcia MT, Coulombel L, Vainchenker W: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. Blood. 2001 Apr 1;97(7):2023-30.
Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T: CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Exp Hematol. 2007 Mar;35(3):490-499.
Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC: CD41 expression defines the onset of primitive and definitive hematopoiesis inthe murine embryo. Development. 2003 Sep;130(18):4393-403.
Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W: Expression of CD41 on hematopoietic progenitors derived from embryonichematopoietic cells. Development. 2002 Apr;129(8):2003-13.
Gene SymbolITGA2B
Gene Full Nameintegrin subunit alpha 2b
Alias SymbolsalphaIIb protein;BDPLT16;BDPLT2;CD41;CD41B;GP2B;GPalpha IIb;GPIIb;GT;GT1;GTA;HPA3;integrin alpha-IIb;integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41);platelet fibrinogen receptor, alpha subunit;platelet glycoprotein IIb of IIb/IIIa complex;platelet membrane glycoprotein IIb;platelet-specific antigen BAK;PPP1R93;protein phosphatase 1, regulatory subunit 93.
NCBI Gene Id3674
Protein NameIntegrin alpha-IIb
Description of TargetIntegrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Uniprot IDP08514
Protein Accession #NP_000410.2
Nucleotide Accession #NM_000419.3
  1. What is the species homology for "ITGA2B Antibody (OAEE00231)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "ITGA2B Antibody (OAEE00231)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "ITGA2B Antibody (OAEE00231)" provided in?

    This item is provided in "Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ITGA2B Antibody (OAEE00231)"?

    This target may also be called "alphaIIb protein;BDPLT16;BDPLT2;CD41;CD41B;GP2B;GPalpha IIb;GPIIb;GT;GT1;GTA;HPA3;integrin alpha-IIb;integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41);platelet fibrinogen receptor, alpha subunit;platelet glycoprotein IIb of IIb/IIIa complex;platelet membrane glycoprotein IIb;platelet-specific antigen BAK;PPP1R93;protein phosphatase 1, regulatory subunit 93." in publications.

  5. What is the shipping cost for "ITGA2B Antibody (OAEE00231)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ITGA2B Antibody (OAEE00231)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ITGA2B Antibody (OAEE00231)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ITGA2B Antibody (OAEE00231)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ITGA2B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ITGA2B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ITGA2B"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ITGA2B"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ITGA2B"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ITGA2B"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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