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ITCH Antibody - middle region (ARP87308_P050)

100 ul
$289.00
In Stock
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Gene Symbol:
ITCH
Official Gene Full Name:
itchy E3 ubiquitin protein ligase
NCBI Gene Id:
83737
Protein Name:
E3 ubiquitin-protein ligase Itchy homolog
Swissprot Id:
Q96J02-3
Protein Accession #:
NP_001244066.1
Nucleotide Accession #:
NM_001257137.2
Alias Symbols:
AIF4, AIP4, ADMFD, NAPP1
Description of Target:
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein Size (# AA):
752
Molecular Weight:
86 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ITCH.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ITCH.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human ITCH
Predicted Species Reactivity:
Human
Tested Species Reactivity:
Human
Peptide Sequence:
Synthetic peptide located within the following region: KPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTS
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide:
For anti-ITCH (ARP87308_P050) antibody is Catalog # AAP87308
Datasheets/Manuals:
Printable datasheet for anti-ITCH (ARP87308_P050) antibody

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