IRF8 Recombinant Protein (OPCD00820)

Catalog No: OPCD00820

IRF8 Recombinant Protein (OPCD00820) using SDS-PAGE

IRF8 Recombinant Protein (OPCD00820) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Arg327
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Irf8
• Gene Full Name: interferon regulatory factor 8
• Alias Symbols: AI893568;IC;Ics;ICSBP;Icsbp1;interferon consensus sequence binding protein 1;interferon consensus sequence-binding protein;interferon regulatory factor 8;IRF;IRF-8;My;Myls.
• NCBI Gene Id: 15900
• Protein Name: Interferon regulatory factor 8
• Description of Target: Plays a role as a transcriptional activator or repressor (By similarity). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (PubMed:22992524).
• Uniprot ID: P23611
• Protein Accession #: NP_001288740.1
• Nucleotide Accession #: NM_001301811.1
• Protein Size (# AA): Met1~Arg327
• Molecular Weight: 41kDa