Catalog No: OPCD00771
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OPCD00771
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Datasheets/ManualsPrintable datasheet for IRF8 Recombinant Protein (OPCD00771)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationCtrl (+), SDS-PAGE, WB
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Gly128-Val426
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolIRF8
Gene Full Nameinterferon regulatory factor 8
Alias SymbolsH-ICSBP;ICSBP;ICSBP1;IMD32A;IMD32B;interferon consensus sequence binding protein 1;Interferon consensus sequence-binding protein;interferon regulatory factor 8;IRF-8.
NCBI Gene Id3394
Protein NameInterferon regulatory factor 8
Description of TargetPlays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).
Uniprot IDQ02556
Protein Accession #NP_002154.1
Nucleotide Accession #NM_002163.2
Protein Size (# AA)Gly128~Val426
Molecular Weight40kDa
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