IRF 3 Protein (OPPA00557)

Catalog No: OPPA00557 (Formerly GWB-31DC9D)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: 1mg/ml in phosphate-buffered saline (PBS), pH 7.4. Physical appearance: Sterile Filtered colorless solution.
• Host: E. Coli
  Product Introduction: Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn-alpha and ifn-beta promoters respectively. IRF-3 does not have any transcription activation domains.
  Product Description: IRF-3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 111 amino acids (1-112) and having a molecular mass of 13 kDa.The Interferon Regulatory Factor-3 is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: Liquid Interferon although stable at 10C for 1 week, should be stored below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Peptide Sequence: MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NS.

Target Info

• Gene Symbol: IRF 3
• Alias Symbols: IIAE7
• NCBI Gene Id: 3661
• Protein Name: Interferon regulatory factor 3
• Description of Target: Recombinant Human Interferon Regulatory Factor-3
• Uniprot ID: Q14653
• Protein Accession #: NP_001562.1
• Protein Size (# AA): Recombinant