IPO9 Antibody - C-terminal region (ARP68445_P050)

Catalog No: ARP68445_P050

Host: Rabbit
Target Name: IPO9
Sample Tissue: Human Hela Whole Cell lysates
Antibody Dilution: 3ug/ml

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human IPO9
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: IRQLASVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRESIS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-IPO9 (ARP68445_P050) antibody is Catalog # AAP68445

Target Info

• Gene Symbol: IPO9
• Gene Full Name: importin 9
• Alias Symbols: Imp9
• NCBI Gene Id: 55705
• Protein Name: Importin-9
• Description of Target: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. Mediates the nuclear import of actin (By similarity).
• Uniprot ID: Q96P70
• Protein Accession #: NP_060555
• Nucleotide Accession #: NM_018085.5
• Protein Size (# AA): 1041
• Molecular Weight: 114 kDa