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INVOLUCRIN Antibody (OAAD00166)

100 ug
$255.00
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Gene Symbol:
IVL
NCBI Gene Id:
3713
Protein Name:
Involucrin
Swissprot Id:
P07476
Replacement Item:
This antibody may replace item sc-15223 from Santa Cruz Biotechnology.
Description of Target:
Involucrin is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. The gene consists of 585 amino acids, 390 of which form a central decapeptide repeat, rich in glutamine and glutamic acid. The involucrin gene, encoding a protein of the terminally differentiated keratinocyte, is polymorphic in the human. Involucrin has previously been mapped to chromosome 1q21. The epidermal protein involucrin has been remodeled in the higher primates. And the existence of two populations of East Asian involucrin alleles gives support for the existence of a Eurasian stem lineage from which Caucasians and a part of the Asian population originated.
Host:
Mouse
Clonality:
Monoclonal
Purification:
Purified by the goat anti-mouse IgG Affinity chromatography.
Application:
WB, IHC, IP, ICC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express IVL.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express IVL.
Immunogen:
Human involucrin
Predicted Species Reactivity:
Human, dog, Pig
Reconstitution and Storage:
At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for longer time.
Datasheets/Manuals:
Printable datasheet for INVOLUCRIN Antibody (OAAD00166) - OAAD00166
Specificity:
Human, dog, pig.
No cross reactivity with other proteins.
Formulation:
Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mg NaN3 as preservative.
Clone:
IL-9
Isotype:
IgG1
Application Info:
Western blot At 2ug/ml with the appropriate system to detect involucrin in cells and tissues.
Immunohistochemistry(P) At 0.4-1ug/ml to detect involucrin in formalin fixed and paraffin embedded tissues.
Immunohistochemistry(F) At 0.4-1ug/ml to detect involucrin in formalin or acetone fixed tissues.
Immunocytochemistry Suitable Other applications have not been tested.
Optimal dilutions should be determined by end user.
Storage Buffer:
1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
Target Reference:
1. Eckert, R. L.; Green, H. : Structure and evolution of the human involucrin gene. Cell 46: 583-589, 1986.
2. Djian, P.; Delhomme, B.; Green, H. : Origin of the polymorphism of the involucrin gene in Asians. Am.
J. Hum. Genet. 56: 1367-1372, 1995.
3. Djian, P.; Delhomme, B.; Green, H. : Origin of the polymorphism of the involucrin gene in Asians. Am.
J. Hum. Genet. 56: 1367-1372, 1995.

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