INSM1 Recombinant Protein (OPCD00202)

Catalog No: OPCD00202

INSM1 Recombinant Protein (OPCD00202) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Lyophilized PBS, pH7.4, containing 0.01% Sarkosyl, 1mM DTT, 5% Trehalose and Proclin300.
• Host: E.coli
• Conjugation: Unconjugated
• Application: SDS-PAGE, WB, ELISA, IP
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Lys278 - Arg518
• Reconstitution and Storage: Reconstitute in ddH₂O to the original concentration prior to lyophilization. If additional dilution is required, dilute further in the original base lyophilization buffer excluding stabilizers such as Sarkosyl, Proclin, Trehalose or Sucrose. Do not vortex. Store at 2-8C for one month. Aliquot and store at -80C for 12 months. Avoid repeated freeze/thaw cycles.
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: Prokaryotic Expressed Recombinant
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: INSM1
• Gene Full Name: insulinoma-associated 1
• Alias Symbols: IA, IA-1
• NCBI Gene Id: 53626
• Protein Name: Insulinoma-associated protein 1
• Description of Target: Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation.
• Uniprot ID: Q63ZV0
• Protein Accession #: NP_058585.2
• Nucleotide Accession #: NM_016889.3
• Molecular Weight: 30 kDa