INHBB Antibody - C-terminal region (OAAB07376)

Catalog No: OAAB07376

Size:400ul

INHBB Antibody (C-term) (Cat. #OAAB07376)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of INHBB Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC-P
  Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
  Cellular Location: Secreted.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This INHBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-397 amino acids from the C-terminal region of human INHBB.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Cow; Chicken; Pig; Rat
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Intended Use: For research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:2000
  WB: 1:1000
  WB: 1:4000
  IHC-P: 1:10~50

Target Info

• Gene Symbol: INHBB
• Alias Symbols: Inhibin beta B chain, Activin beta-B chain, INHBB
• NCBI Gene Id: 3625
• Protein Name: Inhibin beta B chain
• Description of Target: The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
• Uniprot ID: P09529
• Protein Accession #: NP_002184.2
• Molecular Weight: 45 kDa