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INHBA Antibody - N-terminal region (ARP54663_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP54663_P050-FITC Conjugated

ARP54663_P050-HRP Conjugated

ARP54663_P050-Biotin Conjugated

Gene Symbol:
INHBA
Official Gene Full Name:
Inhibin, beta A
NCBI Gene Id:
3624
Protein Name:
Inhibin beta A chain
Swissprot Id:
P08476
Protein Accession #:
NP_002183
Nucleotide Accession #:
NM_002192
Alias Symbols:
EDF, FRP
Replacement Item:
This antibody may replace item sc-121067 from Santa Cruz Biotechnology.
Description of Target:
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Protein Size (# AA):
426
Molecular Weight:
44kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express INHBA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express INHBA.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human INHBA
Predicted Species Reactivity:
Cow, Dog, Goat, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep
Tested Species Reactivity:
Human, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 93%; Goat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%
Complete computational species homology data:
Anti-INHBA (ARP54663_P050)
Peptide Sequence:
Synthetic peptide located within the following region: CPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALL
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
ACVRL1; ACVR2B; ACVR2A; ACVR1; FST; IGSF1; CHRDL2; FSTL3; IGFBP7; ACVR1B; INHBC; TGFBR3; INHBB; INHA; INHBA; ENG;
Blocking Peptide:
For anti-INHBA (ARP54663_P050) antibody is Catalog # AAP54663 (Previous Catalog # AAPP44525)
Datasheets/Manuals:
Printable datasheet for anti-INHBA (ARP54663_P050) antibody
Publications:

Ndiaye, K; Castonguay, A; Benoit, G; Silversides, DW; Lussier, JG; Differential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cells. 9, 71 (2016). WB, Cow, Dog, Goat, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep 27793176

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