INHA Antibody (OASA02972)

Catalog No: OASA02972 (Formerly GWB-Q01139)

Size:200UL

Human testis stained with Mouse anti Human Inhibin alpha, showing Sertoli cells, Leydig cells and spermatogonia. Formalin fixed paraffin processed tissue

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Monoclonal
• Clone: R1
• Isotype: IgG2a
• Host: Mouse
• Application: Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin
• Additional Information: Histology Positive Control Tissue: Normal human ovary/testis
• Reconstitution and Storage: -20°C
• Immunogen: Synthetic peptide comprised of amino acids 1-32 of human inhibin alpha.
• Predicted Homology Based on Immunogen Sequence: Bovine, Sheep. Antibody reactivity and working conditions may vary between species.
• Specificity: Mouse anti Human inhibin alpha anitbody, clone R1 recognizes the alpha subunit of the 32 kDa human inhibin. In western blotting of bovine follicular fluid, bands at 20, 44, and 57 kDa were reported under reducing conditions using clone R1.
• Application Info: IHC-F: Neat-1/100
  IHC-P: Neat-1/100. This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer (pH 6.0) is recommended for this purpose.
• Application Data: Application #1: Human testis stained with Mouse anti Human Inhibin alpha , showing Sertoli cells, Leydig cells and spermatogonia. Formalin fixed paraffin processed tissue
• Reference: 1. Groome, N. G. et al. (1990) Monoclonal and polyclonal antibodies reactive with the 1-32 amino terminal sequence of the alpha subunit of human 32K inhibin. Hybridoma 9: 31-42.
  2. Groome, N. G. et al. (1991) Preparation of monoclonal antibodies to beta A subunit of ovarian inhibin using a synthetic peptide immunogen. Hybridoma 10: 309-316.
  3. Arora, D. S. et al. (1997) Immunohistochemical expression of inhibin/activin subunits in epithelial and granulosa cell tumours of the ovary. J. Pathol. 181: 413-418.
  4. Mylonas, I. et al. (2009) Inhibin-alpha subunit is an independent prognostic parameter in human endometrial carcinomas: analysis of inhibin/activin-alpha, -betaA and -betaB subunits in 302 cases. Eur. J. Cancer. 45: 1304-1314.
  5. Schraith, D. et al. (2003) Alpha-inhibin immunoreactivity in soft-tissue neoplasia. Mod. Pathol. 16: 1205-1209.
  

Target Info

• Gene Symbol: INHA
• Alias Symbols: INHA
• NCBI Gene Id: 3623
• Protein Name: Inhibin alpha chain
• Description of Target: The alpha subunit of human inhibin is a glycoprotein which acts to suppress follicle-stimulating hormone (FSH) secretion. Inhibin alpha is expressed in a range of tissues including the endometrium, brain, adrenal gland, testis, and ovary. The antibody may be of value in the differentiation of adrenocortical tumors, placental and gestational trophoblastic lesions, and sex cord stromal tumors.
• Uniprot ID: P05111
• Protein Accession #: NP_002182.1
• Protein Size (# AA): 366