Catalog No: ARP54366_P050
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ARP54366_P050
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Datasheets/ManualsPrintable datasheet for anti-IMPDH2 (ARP54366_P050) antibody
Product Info
ReferenceGrinyo,J., (er) Transpl. Int. (2008) In press
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human IMPDH2
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 92%; Zebrafish: 93%
Peptide SequenceSynthetic peptide located within the following region: SCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
Concentration0.5 mg/ml
Blocking PeptideFor anti-IMPDH2 (ARP54366_P050) antibody is Catalog # AAP54366 (Previous Catalog # AAPP31141)
Gene SymbolIMPDH2
Gene Full NameIMP (inosine 5'-monophosphate) dehydrogenase 2
Alias SymbolsIMPD2, IMPDH-II
NCBI Gene Id3615
Protein NameInosine-5'-monophosphate dehydrogenase 2
Description of TargetIMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. It catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Uniprot IDP12268
Protein Accession #NP_000875
Nucleotide Accession #NM_000884
Protein Size (# AA)514
Molecular Weight56kDa
Protein InteractionsRSG1; APIP; HUWE1; UBC; IMPDH2; CDK2; RPA1; RPA3; RPA2; PRKAR2A; IMPDH1; EIF2S3; PARK2; MAPK10; SOX2; NPM1; PEX14; FN1; RPLP0P6; RPS6; RPL15; FOLR1; FBXO6; GRB2; UBQLN4; PIAS4; COPS5; COPS6; CUL3; YWHAZ; FBXO25; SIRT7; HDAC5; MME; SUMO4; AKT1; IKBKE; ATG5
  1. What is the species homology for "IMPDH2 Antibody - C-terminal region (ARP54366_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish".

  2. How long will it take to receive "IMPDH2 Antibody - C-terminal region (ARP54366_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "IMPDH2 Antibody - C-terminal region (ARP54366_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "IMPDH2 Antibody - C-terminal region (ARP54366_P050)"?

    This target may also be called "IMPD2, IMPDH-II" in publications.

  5. What is the shipping cost for "IMPDH2 Antibody - C-terminal region (ARP54366_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "IMPDH2 Antibody - C-terminal region (ARP54366_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "IMPDH2 Antibody - C-terminal region (ARP54366_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "56kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "IMPDH2 Antibody - C-terminal region (ARP54366_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "IMPDH2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "IMPDH2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "IMPDH2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "IMPDH2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "IMPDH2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "IMPDH2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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