Catalog No: OPPA02563 (Formerly GWB-BSP216)
Size:5UG
Price: $75.00
SKU
OPPA02563
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IMPA1 Protein (OPPA02563)

Datasheets/ManualsPrintable datasheet for OPPA02563
Product Info
Predicted Species ReactivityHuman
Product FormatThe IMPA1 solution (1 mg/ml) contains 20 mM Tris-HCl Buffer (pH 8.0) and 10% Glycerol. Physical appearance: Sterile Filtered colorless solution.
HostE. Coli
::Product Introduction: Inositol monophosphatase1 (IMPA1) is responsible for the provision of inositol essential for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA1 has a central role in the phosphatidylinositol signaling pathway by catalyzing the hydrolysis of inositol monophosphates. IMPA1 has been recognized as the pharmacological target for lithium action in the brain. The IMPA1 enzyme has a magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and ensuing depletion of inositol for phosphatidylinositol synthesis may perhaps explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder.
Product Description: IMPA1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 297 amino acids (1-277 a.a.) and having a molecular mass of 32.3kDa. The IMPA1 is purified by proprietary chromatographic techniques.
Reconstitution and StorageIMPA1 should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
PurityGreater than 95.0% as determined by SDS-PAGE.
Peptide SequenceMGSSHHHHHH SSGLVPRGSH MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE KYPSHSFIGE ESVAAGEKSI LTDNPTWIID PIDGTTNFVH RFPFVAVSIG FAVNKKIEFG VVYSCVEGKM YTARKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRTPE TVRMVLSNME KLFCIPVHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD VAGAGIIVTE AGGVLMDVTG GPFDLMSRRV IAANNRILAE RIAKEIQVIP LQRDDED.
Gene SymbolIMPA1
Alias SymbolsIMP, IMPA, MRT59
NCBI Gene Id3612
Protein NameInositol monophosphatase 1
Description of TargetRecombinant Human Inositol Monophosphatase 1
Uniprot IDP29218
Protein Accession #NP_001138350.1
Protein Size (# AA)Recombinant
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