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IL7R Antibody : APC (OATA00070)

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Tested Species Reactivity:
Mouse
Product Format:
Liquid. 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Clonality:
Monoclonal
Clone:
A7R34
Isotype:
Rat IgG2a, kappa
Host:
Rat
Conjugation:
APC: Allophycocyanin
Application:
FC
:::
Excitation Laser: Red (633-640 nm)
:::
Emmision: 660 nm
Reconstitution and Storage:
2-8C protected from light
Gene Symbol:
IL7R
NCBI Gene Id:
16172
Official Gene Full Name:
interleukin 7 receptor
Protein Name:
interleukin-7 receptor subunit alpha
Swissprot Id:
P16872
Protein Accession #:
NP_032398.3
Nucleotide Accession #:
NM_008372.4
Alias Symbols:
CD127, IL-7Ralpha
Description of Target:
Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express IL7R.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express IL7R.
Datasheets/Manuals:
Printable datasheet for OATA00070
Specificity:
CD127 (IL-7Ra)
Application Info:
This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indicated). Please refer to the figure legend for the optimal concentration used to stain the tissue shown. We recommend titrating the antibody under your specific conditions to determine the optimal concentration of antibody needed in your experimental system.
Target Reference:

Thaventhiran JED, Hoffmann A, Magiera L, de la Roche M, Lingel H, Brunner-Weinzierl M, and Fearon DT. 2012. Proc. Natl. Acad. Sci. 10.1073. (Flow cytometry).

Jin J, Goldschneider I, and Lai L. 2011. J. Immunol. 186: 1915-1922. (in vivo activation)

Vondenhoff MF, Greuter M, Goverse G, Elewaut D, Dewint P, Ware CF, Hoorweg K, Kraal G, and Mebius RE. 2009. J. Immunol. 182(9): 5439-5445. (Immunofluorescence microscopy - frozen tissue)

Leithauser F, Meinhardt-Krajina T, Fink K, Wotschke B, Moller P and Reimann J. 2006. Am. J. Pathol. 168(6): 1898-1909. (Immunohistochemistry - frozen tissue)

Seddon B and Zamoyska R. 2002. J. Immunol. 169: 2997-3005. (in vivo activation)

Sudo T, Nishikawa S, Ohno N, Akiyama N, Tamakoshi M, Yoshida H and Nishikawa S-I. 1993. Proc. Natl. Acad. Sci. 90: 9125-9129. (in vitro and in vivo blocking; Immunoprecipitation)

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