IL6ST Recombinant Protein (OPCD00255)

Catalog No: OPCD00255

IL6ST Recombinant Protein (OPCD00255) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Rat
• Product Format: Lyophilized PBS, pH7.4, containing 0.01% Sarkosyl, 1mM DTT, 5% Trehalose and Proclin300.
• Host: E.coli
• Conjugation: Unconjugated
• Application: SDS-PAGE, WB, ELISA, IP
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Glu26-Asp323
• Reconstitution and Storage: Reconstitute in ddH₂O to the original concentration prior to lyophilization. If additional dilution is required, dilute further in the original base lyophilization buffer excluding stabilizers such as Sarkosyl, Proclin, Trehalose or Sucrose. Do not vortex. Store at 2-8C for one month. Aliquot and store at -80C for 12 months. Avoid repeated freeze/thaw cycles.
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: Prokaryotic Expressed Recombinant
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: IL6ST
• Alias Symbols: Ac1055, gp130, Gp130, Il-6rb, IL-6RB, IL-6R-beta, IL-6 receptor subunit beta, IL-6R subunit beta, Interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, Oncostatin-M receptor subunit alpha
• Protein Name: Interleukin-6 receptor subunit beta
• Description of Target: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition.
• Uniprot ID: P40190
• Molecular Weight: 64 kDa