IL6ST Antibody (OAAF00983)

Catalog No: OAAF00983 (Formerly GWB-ASC391)

Size:100 ug

Western blot analysis of extracts from Jurkat cells, using CD130/gp130 Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CD130/gp130 Antibody. The picture on the right is treated with the synthesized peptide.

Immunofluorescence analysis of NIH-3T3 cells, using CD130/gp130 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human CD130/gp130.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: CD130/gp130 (Ab-782) antibody detects endogenous levels of total CD130/gp130 protein
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Reference: Hans-Heinrich Oberg, Int. Immunol., Apr 2006; 18: 555 - 563.
  Ursula Horsten, J. Biol. Chem., Sep 1997; 272: 23748.
  Gerhard Müller-Newen, J. Immunol., Dec 1998; 161: 6347.
  UA Betz, Int. Immunol., Aug 1998; 10: 1175 - 1184.

Target Info

• Gene Symbol: IL6ST
• Gene Full Name: interleukin 6 cytokine family signal transducer
• Alias Symbols: CD130;CD130 antigen;CDW130;GP130;gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form;gp130, oncostatin M receptor;HIES4;IL-6 receptor subunit beta;IL-6R subunit beta;IL-6RB;interleukin receptor beta chain;interleukin-6 receptor subunit beta;interleukin-6 signal transducer;membrane glycoprotein 130;membrane glycoprotein gp130;oncostatin-M receptor subunit alpha;sGP130.
• NCBI Gene Id: 3572
• Protein Name: Interleukin-6 receptor subunit beta
• Description of Target: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
• Uniprot ID: P40189
• Protein Accession #: NP_001177910.1
• Molecular Weight: 103 kDa